Not Human Subjects Research (NHSR) means that the research activity is not regulated by the IRB in any way because the activity is not considered human subjects research. A study would not be considered human subjects research if the answer to the questions “is it research as defined by the federal regulations?” or “is it human subjects research as defined by the federal regulations?” is no. Answering “no” to either of those questions means the IRB does not have jurisdiction to review the project and no IRB approval is necessary. Note, this determination is different from a study reviewed and determined to be Exempt.